Five women--including a high school teacher, a pregnant teenager, and a forest-dwelling homeopath--struggle with changes in a near-future America where abortion and assisted fertility have been outlawed and where the homeopath is targeted by a modern-day witch hunt. Abortion is illegal in America, in-vitro fertilization is banned, and the Personhood Amendment grants rights of life, liberty, and property to every embryo. In a small Oregon fishing town Ro, a single high-school teacher, is trying to have a baby on her own. Susan is a frustrated mother of two, trapped in a crumbling marriage. Mattie is the adopted daughter of doting parents and one of Ro's best students, who finds herself pregnant with nowhere to turn. And Gin is the gifted, forest-dwelling herbalist, or "mender," who brings all their fates together when she's arrested and put on trial in a frenzied modern-day witch hunt.